Regulation of STATs by polycystin-1 and their role in polycystic kidney disease

@inproceedings{Weimbs2013RegulationOS,
  title={Regulation of STATs by polycystin-1 and their role in polycystic kidney disease},
  author={Thomas Weimbs and Erin E Olsan and Jeffrey J. Talbot},
  booktitle={JAK-STAT},
  year={2013}
}
Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT transcription factors by a novel, dual mechanism. STAT3 and STAT6 are aberrantly activated in renal cysts. Genetic and pharmacological approaches to inhibit STAT3 or STAT6 have led to promising results in ADPKD mouse models. Here, we review current findings that lead to a model of PC1 as a key regulator of STAT signaling in renal… CONTINUE READING
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