Regulation of STAT3 by direct binding to the Rac1 GTPase.

  title={Regulation of STAT3 by direct binding to the Rac1 GTPase.},
  author={Amy R. Simon and Haris G. Vikis and Suzanne L K Stewart and Barry L. Fanburg and Brent H Cochran and Kunliang Guan},
  volume={290 5489},
The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after stimulation of cells with growth factors or cytokines. We show that the Rac1 guanosine triphosphatase can bind to and regulate STAT3 activity. Dominant negative Rac1 inhibited STAT3 activation by growth factors, whereas activated Rac1 stimulated STAT3 phosphorylation on both tyrosine and serine residues. Moreover, activated Rac1 formed a… CONTINUE READING
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