Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1.

@article{Yesilaltay2005RegulationOS,
  title={Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1.},
  author={Ayce Yesilaltay and Olivier Kocher and Attilio A Rigotti and Monty Krieger},
  journal={Current opinion in lipidology},
  year={2005},
  volume={16 2},
  pages={
          147-52
        }
}
PURPOSE OF REVIEW A novel mechanism for the regulation of lipoprotein receptor activity is providing new insights into the control of lipid metabolism. The tissue-specific adaptors ARH (autosomal recessive hypercholesterolemia) and PDZK1 [where PDZ derives from postsynaptic density protein (PSD-95)/Drosophila discs-large (dlg)/tight-junction protein (ZO1)] have been shown to control the activities of distinct types of lipoprotein receptors in a posttranscriptional fashion, significantly… CONTINUE READING

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