Regulation of SIRT6 protein levels by nutrient availability.

@article{Kanfi2008RegulationOS,
  title={Regulation of SIRT6 protein levels by nutrient availability.},
  author={Yariv Kanfi and Ronnie Shalman and Victoria Peshti and Shmuel N Pilosof and Yosi M Gozlan and Kevin J Pearson and Batya Lerrer and Danesh Moazed and Jean-Christophe Marine and Rafael de Cabo and Haim Y Cohen},
  journal={FEBS letters},
  year={2008},
  volume={582 5},
  pages={
          543-8
        }
}
Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in… CONTINUE READING

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