Regulation of S100A10 by the PML-RAR-α oncoprotein.

@article{OConnell2011RegulationOS,
  title={Regulation of S100A10 by the PML-RAR-α oncoprotein.},
  author={Paul A. O'Connell and Patr{\'i}cia A Madureira and Jason N Berman and Robert Stefan Liwski and David. M. Waisman},
  journal={Blood},
  year={2011},
  volume={117 15},
  pages={4095-105}
}
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia that results from the expression of the promyelocytic leukemia-retinoic acid receptor α (PML-RAR-α) oncoprotein. It is characterized by severe hemorrhagic complications due in part to excessive fibrinolysis, resulting from the excessive generation of the fibrinolytic enzyme, plasmin, at the cell surface of the PML cells. The treatment of patients with all-trans retinoic acid (ATRA) effectively ameliorates the… CONTINUE READING

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