Regulation of Repair by the 26S Proteasome

  title={Regulation of Repair by the 26S Proteasome},
  author={Kevin S. Sweder and Kiran Madura},
  journal={Journal of Biomedicine and Biotechnology},
  pages={94 - 105}
Cellular processes such as transcription and DNA repair may be regulated through diverse mechanisms, including RNA synthesis, protein synthesis, posttranslational modification and protein degradation. The 26S proteasome, which is responsible for degrading a broad spectrum of proteins, has been shown to interact with several nucleotide excision repair proteins, including xeroderma pigmentosum B protein (XPB), Rad4, and Rad23. Rad4 and Rad23 form a complex that binds preferentially to UV-damaged… CONTINUE READING


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