Regulation of RelB expression during the initiation of dendritic cell differentiation.

  title={Regulation of RelB expression during the initiation of dendritic cell differentiation.},
  author={Pedro J. Cejas and Louise M. Carlson and Despina Kolonias and Jian Zhang and Inna Lindner and Daniel D Billadeau and Lawrence H. Boise and Kelvin P Lee},
  journal={Molecular and cellular biology},
  volume={25 17},
The transcription factor RelB is required for proper development and function of dendritic cells (DCs), and its expression is upregulated early during differentiation from a variety of progenitors. We explored this mechanism of upregulation in the KG1 cell line model of a DC progenitor and in the differentiation-resistant KG1a subline. RelB expression is relatively higher in untreated KG1a cells but is upregulated only during differentiation of KG1 by an early enhancement of transcriptional… CONTINUE READING


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