Regulation of Raf through phosphorylation and N terminus-C terminus interaction.

  title={Regulation of Raf through phosphorylation and N terminus-C terminus interaction.},
  author={Huira Chong and Kun Liang Guan},
  journal={The Journal of biological chemistry},
  volume={278 38},
Raf kinase is a key component in regulating the MAPK pathway. B-Raf has been reported as an oncogene and is mutated in 60% of human melanomas. The main focus of Raf regulation studies has been on phosphorylation, dephosphorylation, and scaffolding proteins; however, Raf also has its own auto-regulatory domain. Removal of the N-terminal regulatory domain, initially discovered in the viral Raf oncogene (v-Raf), results in a kinase domain with high basal activity independent of Ras activation. In… CONTINUE READING

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