Regulation of Raf-Akt Cross-talk.

  title={Regulation of Raf-Akt Cross-talk.},
  author={Karin Moelling and Karen Schad and Magnus Bosse and Sven Zimmermann and Marc Schweneker},
  journal={The Journal of biological chemistry},
  volume={277 34},
We have recently shown that the Ras-Raf-MEK-ERK and phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathways can cross-talk in the human breast cancer cell line MCF-7. High Raf activity induces growth arrest and differentiation in these cells, whereas high PI3K/Akt activity correlates with cell survival and proliferation. Here we show that the Raf-Akt cross-talk is regulated in a concentration- and ligand-dependent manner. High doses of insulin-like growth factor I (IGF-I) activate Akt… CONTINUE READING
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Regulation of Raf-Akt Cross-talk

  • J. Lovric, K. Moelling
  • Oncogene
  • 1996

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