Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading.

Abstract

The pertussis toxin-sensitive G protein, G(i), has been implicated in lysophosphatidic acid-induced cell mitogenesis and migration, but the mechanisms remain to be detailed. In the present study, we found that pertussis toxin blocks lysophosphatidic acid-induced cell spreading of NIH 3T3 fibroblasts on fibronectin. This prevention of cell spreading was… (More)

Topics

  • Presentations referencing similar topics