Regulation of ROS Production and Vascular Function by Carbon Monoxide

  title={Regulation of ROS Production and Vascular Function by Carbon Monoxide},
  author={Yoon Kyung Choi and Elaine D Por and Young-Guen Kwon and Young-Myeong Kim},
  journal={Oxidative Medicine and Cellular Longevity},
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). CO interacts with reduced iron of heme-containing proteins, leading to its involvement in various cellular events via its production of mitochondrial reactive oxygen species (ROS). CO-mediated ROS production initiates intracellular signal events, which regulate the expression of adaptive genes implicated in oxidative stress and functions as signaling molecule for promoting vascular functions, including… 

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