Regulation of ROCK Activity in Cancer

  title={Regulation of ROCK Activity in Cancer},
  author={Marie Morgan-Fisher and Ulla M. Wewer and Atsuko Yoneda},
  booktitle={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
Cancer-associated changes in cellular behavior, such as modified cell-cell contact, increased migratory potential, and generation of cellular force, all require alteration of the cytoskeleton. Two homologous mammalian serine/threonine kinases, Rho-associated protein kinases (ROCK I and II), are key regulators of the actin cytoskeleton acting downstream of the small GTPase Rho. ROCK is associated with cancer progression, and ROCK protein expression is elevated in several types of cancer. ROCKs… CONTINUE READING