Regulation of RGS mRNAs by cAMP in PC12 cells.

  title={Regulation of RGS mRNAs by cAMP in PC12 cells.},
  author={D J Pepperl and S Shah-Basu and Donald VanLeeuwen and James G. Granneman and Robert G Mackenzie},
  journal={Biochemical and biophysical research communications},
  volume={243 1},
The RGS (regulators of G protein signaling) proteins represent a novel family of proteins which attenuate G protein mediated signaling. Using antisense riboprobes selective for rat RGS4, RGS7, and RGS2, we examined the regulation of these RGS mRNAs in PC12 cells in response to agents which elevate intracellular cAMP. Treatment of the PC12 cells with forskolin, dibutryl cAMP, or 8-CPT-cAMP for three hours decreased RGS4 message by nearly 50%. Actinomycin D, a potent inhibitor of transcription… CONTINUE READING