Regulation of RAF protein kinases in ERK signalling

  title={Regulation of RAF protein kinases in ERK signalling},
  author={Hugo Lavoie and M. C. Therrien},
  journal={Nature Reviews Molecular Cell Biology},
RAF family kinases were among the first oncoproteins to be described more than 30 years ago. They primarily act as signalling relays downstream of RAS, and their close ties to cancer have fuelled a large number of studies. However, we still lack a systems-level understanding of their regulation and mode of action. The recent discovery that the catalytic activity of RAF depends on an allosteric mechanism driven by kinase domain dimerization is providing a vital new piece of information towards a… CONTINUE READING
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