Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells.

@article{Yamamoto2006RegulationOP,
  title={Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells.},
  author={Naoka Yamamoto and Nobutaka Yamamoto and Matthew W. Petroll and James V. Jester and Harrison Dwight Cavanagh},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 8},
  pages={3430-40}
}
PURPOSE To determine the effects of contact lenses (CLs) and Pseudomonas aeruginosa (PA) infection on localization of cystic fibrosis transmembrane conductance regulator (CFTR) on corneal surface epithelial cells and the association between lipid raft formation and CFTR in mediating PA binding and internalization in ocular surface epithelium. METHODS CFTR immunolocalization was evaluated in vivo in rabbit corneal-conjunctival epithelium (with/without CL wear) before and after PA exposure and… CONTINUE READING
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