Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway

@inproceedings{Kim2010RegulationOP,
  title={Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway},
  author={Donghwa Kim and Shaokun Shu and Marc D. Coppola and Satoshi Kaneko and Zeng-qiang Yuan and Jin Quan Cheng},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Hippo, a Drosophila serine/threonine kinase, promotes apoptosis and restricts cell growth and proliferation. Its mammalian homolog MST2 has been shown to play similar role and be regulated by Raf-1 via a kinase-independent mechanism and by RASSF family proteins through forming complex with MST2. However, regulation of MST2 by cell survival signal remains largely unknown. METHODOLOGY/PRINCIPAL FINDINGS Using immunoblotting, in vitro kinase and in vivo labeling assays, we show that… CONTINUE READING

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