Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

  title={Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release},
  author={Ceren Korkut and Yihang Li and Kate Koles and Cassandra Brewer and James A. Ashley and Motojiro Yoshihara and Vivian Budnik},
Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by… CONTINUE READING
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