Regulation of Pluripotency and Self- Renewal of ESCs through Epigenetic- Threshold Modulation and mRNA Pruning

@article{Jia2012RegulationOP,
  title={Regulation of Pluripotency and Self- Renewal of ESCs through Epigenetic- Threshold Modulation and mRNA Pruning},
  author={Junling Jia and Xiaobin Zheng and Gangqing Hu and Kairong Cui and Junqi Zhang and Anying Zhang and Hao Jiang and Bingwen Lu and John Yates and Chengyu Liu and Keji Zhao and Yixian Zheng},
  journal={Cell},
  year={2012},
  volume={151},
  pages={576-589}
}
Embryonic stem cell (ESC) pluripotency requires bivalent epigenetic modifications of key developmental genes regulated by various transcription factors and chromatin-modifying enzymes. How these factors coordinate with one another to maintain the bivalent chromatin state so that ESCs can undergo rapid self-renewal while retaining pluripotency is poorly understood. We report that Utf1, a target of Oct4 and Sox2, is a bivalent chromatin component that buffers poised states of bivalent genes. By… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
29 Citations
59 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Similar Papers

Loading similar papers…