Regulation of Pituitary ACTH Secretion during Chronic Stress

  title={Regulation of Pituitary ACTH Secretion during Chronic Stress},
  author={Greti Aguilera},
  journal={Frontiers in Neuroendocrinology},
  • G. Aguilera
  • Published 1 December 1994
  • Biology, Medicine
  • Frontiers in Neuroendocrinology
Maintenance of adequate levels of response of the hypothalamic-pituitary-adrenal axis during chronic stress is important for survival. Three basic patterns of response can be identified depending on the type of stress: (a) desensitization of ACTH responses to the sustained stimulus, but hyperresponsiveness to a novel stress despite elevated plasma glucocorticoid levels, as occurs in physical-psychological paradigms; (b) no desensitization of ACTH response to the repeated stimulus and… 

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