Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.

  title={Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.},
  author={Morgan Goulding and Andrew G. S. Lumsden and Alice J. Paquette},
  volume={120 4},
The segmented mesoderm in vertebrates gives rise to a variety of cell types in the embryo including the axial skeleton and muscle. A number of transcription factors containing a paired domain (Pax proteins) are expressed in the segmented mesoderm during embryogenesis. These include Pax-3 and a closely related gene, Pax-7, both of which are expressed in the segmental plate and in the dermomyotome. In this paper, we show that signals from the notochord pattern the expression of Pax-3, Pax-7 and… CONTINUE READING
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