Regulation of Pancreatic-Cell Glucokinase From Basics to Therapeutics

  title={Regulation of Pancreatic-Cell Glucokinase From Basics to Therapeutics},
  author={Franz M. Matschinsky},
Glucokinase (GK) serves as glucose sensor in pancreatic -cells and in other glucose sensor cells in the body. Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits. Mathematical modeling of the kinetic data of recombinant human wild-type and mutant GK accurately predicts the effects of GK mutations on the threshold of glucose… CONTINUE READING
36 Citations
59 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 36 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

Glucokinase. In Encyclopedia of Molecular Medicine

  • GI Bell, A Cuesta-Munoz, FM Matschinsky
  • 2002
Highly Influential
5 Excerpts

Glucokinase”: its regulation and role in liver metabolism

  • ML Cardenas
  • In Molecular Biology Intelligence Unit. Lands RG,
  • 1995
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…