Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand.

@article{Willy2004RegulationOP,
  title={Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand.},
  author={Patricia J. Willy and Ian R. Murray and Jing Qian and Brett B Busch and William Stevens and Richard Tyler Martin and Raju Mohan and Sihong Zhou and Peter Ordentlich and Ping Wei and Douglas W. Sapp and Robert A. Horlick and Richard A. Heyman and Ira G. Schulman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 24},
  pages={8912-7}
}
Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha) is a transcriptional coactivator that is a key component in the regulation of energy production and utilization in metabolic tissues. Recent work has identified PGC-1alpha as a strong coactivator of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha), implicating ERRalpha as a potential mediator of PGC-1alpha action. To understand the role of ERRalpha in PGC-1alpha signaling, a… CONTINUE READING

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