Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

@article{Daitoku2003RegulationOP,
  title={Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.},
  author={Hiroaki Daitoku and Kazuyuki Yamagata and Hitomi Matsuzaki and Mitsutoki Hatta and Akiyoshi Fukamizu},
  journal={Diabetes},
  year={2003},
  volume={52 3},
  pages={642-9}
}
Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) plays a major role in mediating hepatic gluconeogenesis in response to starvation, during which PGC-1 is induced by the cyclic AMP response element binding protein. Although it is observed that insulin counteracts PGC-1 transcription, the mechanism by which insulin suppresses the transcription of PGC-1 is still unclear. Here, we show that forkhead transcription factor FKHR contributes to mediating the effects of insulin on… CONTINUE READING
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