Regulation of PGC-1α Isoform Expression in Skeletal Muscles

@inproceedings{Popov2015RegulationOP,
  title={Regulation of PGC-1α Isoform Expression in Skeletal Muscles},
  author={D. V. Popov and Evgeny A Lysenko and Ilya V Kuzmin and Vinogradova Vinogradova and A. I. Grigoriev},
  booktitle={Acta naturae},
  year={2015}
}
The coactivator PGC-1α is the key regulator of mitochondrial biogenesis in skeletal muscle. Skeletal muscle expresses several PGC-1α isoforms. This review covers the functional role of PGC-1α isoforms and the regulation of their exercise-associated expression in skeletal muscle. The patterns of PGC-1α mRNA expression may markedly differ at rest and after muscle activity. Different signaling pathways are activated by different physiological stimuli, which regulate the expression of the PGC-1… CONTINUE READING
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