Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.

Abstract

Tyrosine phosphorylation of linker proteins enables the T cell antigen receptor (TCR)-associated protein tyrosine kinases to phosphorylate and regulate effector molecules that generate second messengers. We demonstrate here that the SLP-76 linker protein interacts with both nck, an adaptor protein, and Vav, a guanine nucleotide exchange factor for Rho… (More)

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@article{Wardenburg1998RegulationOP, title={Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.}, author={Juliane Bubeck Wardenburg and Rajita Pappu and Junguo Bu and Bruce J Mayer and Jonathan Chernoff and David B Straus and Alexander Chak-Lam Chan}, journal={Immunity}, year={1998}, volume={9 5}, pages={607-16} }