Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes.

@article{Ashraf2011RegulationOP,
  title={Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes.},
  author={Tamima Ashraf and Patrick T Ronaldson and Yuri Persidsky and Reina Bendayan},
  journal={Journal of neuroscience research},
  year={2011},
  volume={89 11},
  pages={1773-82}
}
P-glycoprotein (P-gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P-gp functional expression in rat astrocytes, a cellular reservoir of HIV-1. However, whether P-gp is regulated in a similar way in human astrocytes is unknown. This study investigates the regulation of P… CONTINUE READING
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