Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

@article{He2002RegulationOO,
  title={Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization},
  author={Li He and Jamie Fong and Mark Zastrow and Jennifer L. Whistler},
  journal={Cell},
  year={2002},
  volume={108},
  pages={271-282}
}
The utility of morphine for the treatment of chronic pain is hindered by the development of tolerance to the analgesic effects of the drug. Morphine is unique among opiates in its ability to activate the mu opioid receptor (MOR) without promoting its desensitization and endocytosis. Here we demonstrate that [D-Ala(2)-MePhe(4)-Gly(5)-ol] enkephalin (DAMGO) can facilitate the ability of morphine to stimulate MOR endocytosis. As a consequence, rats treated chronically with both drugs show reduced… 
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TLDR
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