Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

@article{He2002RegulationOO,
  title={Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization},
  author={Li He and Jamie Fong and Mark Zastrow and Jennifer L. Whistler},
  journal={Cell},
  year={2002},
  volume={108},
  pages={271-282}
}
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It is demonstrated that arrestins play a fundamental role in mediating this agonist-selective regulation of opioid receptors with arrestins and that morphine-activated μ receptors fail to undergo arrestin-dependent uncoupling from cognate G proteins.
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It is demonstrated that arrestins play a fundamental role in mediating this agonist-selective regulation of opioid receptors with arrestins and that morphine-activated mu receptors fail to undergo arrestin-dependent uncoupling from cognate G proteins.
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It is shown that in mice lacking beta-arrestin-2, desensitization of the mu-opioid receptor does not occur after chronic morphine treatment, and that these animals fail to develop antinociceptive tolerance.
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