Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization
@article{He2002RegulationOO, title={Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization}, author={Li He and Jamie Fong and Mark Zastrow and Jennifer L. Whistler}, journal={Cell}, year={2002}, volume={108}, pages={271-282} }
330 Citations
Opioid regulation of mu receptor internalisation: relevance to the development of tolerance and dependence.
- BiologyCNS & neurological disorders drug targets
- 2010
Experiments performed using both transfected cell systems and ex vivo/in vivo models have provided evidence that when morphine can promote internalisation of the mu receptor there is a decrease in the development of tolerance and dependence.
Receptor trafficking induced by μ-opioid-receptor phosphorylation
- BiologyNeuroscience & Biobehavioral Reviews
- 2009
Receptor Endocytosis Counteracts the Development of Opioid Tolerance
- BiologyMolecular Pharmacology
- 2005
It is demonstrated that the endocytotic potencies of opioid drugs are negatively correlated with their ability to cause receptor desensitization and opioid tolerance in HEK 293 cells, and shown that agonist-induced receptor endocytic facilitates the compensatory up-regulation of the cAMP pathway, a cellular hallmark of opioid withdrawal.
Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence
- BiologyCurrent Biology
- 2008
Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs
- Biology, PsychologyCurrent Opinion in Neurobiology
- 2003
Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice
- BiologyScientific Reports
- 2019
Findings suggest convallatoxin are potentially therapeutic for morphine side effects and open a new avenue to study MOR trafficking.
Opioid receptor trafficking and interaction in nociceptors
- BiologyBritish journal of pharmacology
- 2015
Analysis of the molecular, cellular and neural circuit mechanisms that regulate the trafficking and interaction of opioid receptors and related signalling molecules in the pain pathway would help to elucidate the mechanism of opiate analgesia and improve pain therapy.
Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance.
- BiologyTrends in pharmacological sciences
- 2006
Experiments in animals show that MOP-receptor-mediated spinal analgesia is enhanced and morphine tolerance does not develop when DOP receptor functions are pharmacologically or genetically attenuated, indicating that the delivery and trafficking of DOP receptors are crucial processes that modulate opioid analgesia and tolerance.
References
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Investigation of the behavioural effects of morphine reveals that a lack of μ receptors abolishes the analgesic effect of morphine, as well as place-preference activity and physical dependence, and concludes that the µ-opioid-receptor gene product is a mandatory component of the opioid system for morphine action.