Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.

@article{Wu2011RegulationON,
  title={Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.},
  author={Hua Wu and Yayu Lin and Wengang Li and Zhe Sun and Weiwei Gao and H. P. Zhang and Lei Xie and Fuquan Jiang and Bin Qin and Tingdong Yan and Liqun Chen and Yi Zhao and Xihua Cao and Yin Wu and Bingzhen Lin and Hu Zhou and Alice S. Wong and Xiaokun Zhang and Jin-zhang Zeng},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 1},
  pages={192-205}
}
The orphan nuclear receptor Nur77 is an immediate-early response gene whose expression is rapidly induced by various extracellular stimuli. The aims of this study were to study the role of Nur77 expression in the growth and survival of colon cancer cells and the mechanism by which Nur77 expression was regulated. We showed that levels of Nur77 were elevated in a majority of human colon tumors (9/12) compared to their nontumorous tissues and that Nur77 expression could be strongly induced by… CONTINUE READING

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