Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.

@article{Muqeem2018RegulationON,
  title={Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.},
  author={Tanziyah Muqeem and Biswarup Ghosh and V{\'i}tor Pinto and Angelo C Lepore and Manuel Covarrubias},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2018},
  volume={38 15},
  pages={
          3729-3740
        }
}
Presynaptic voltage-gated K+ (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission in the spinal dorsal horn. However, the Kv channel subtypes responsible for this critical role have not been identified. The Kv3.4 channel is particularly important because it is robustly expressed in DRG nociceptors, where it regulates action potential (AP) duration. Furthermore, Kv3.4 dysfunction is implicated in the pathophysiology of neuropathic pain in… CONTINUE READING
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