Regulation of Nm23-H1 and cell invasiveness by Kaposi's sarcoma-associated herpesvirus.

@article{Qin2011RegulationON,
  title={Regulation of Nm23-H1 and cell invasiveness by Kaposi's sarcoma-associated herpesvirus.},
  author={Zhiqiang Qin and Lu Dai and Bryan P. Toole and Erle Robertson and Chris H. Parsons},
  journal={Journal of virology},
  year={2011},
  volume={85 7},
  pages={3596-606}
}
The Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), and the induction of an invasive cellular phenotype by KSHV following de novo infection is an important pathogenic component mediating tumor progression. The metastasis suppressor gene known as Nm23-H1 regulates tumor cell invasiveness, but whether KSHV itself regulates Nm23-H1 expression or subcellular localization, and whether this impacts cell invasiveness, has not been established. We found… CONTINUE READING
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