Regulation of Neuropeptide Y Release by Neuropeptide Y Receptor Ligands and Calcium Channel Antagonists in Hypothalamic Slices

@article{King1999RegulationON,
  title={Regulation of Neuropeptide Y Release by Neuropeptide Y Receptor Ligands and Calcium Channel Antagonists in Hypothalamic Slices},
  author={Peter J King and Peter S. Widdowson and Henri N. Doods and G. Williams},
  journal={Journal of Neurochemistry},
  year={1999},
  volume={73}
}
Abstract : Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We investigated the regulation of endogenous NPY release from rat hypothalamic slices by NPY receptor ligands and calcium channel antagonists. High‐potassium stimulation (60 mM) of the slices produced a calcium‐dependent threefold increase in NPY release above basal release. The Y2 receptor agonists NPY(13‐36) and N‐acetyl[Leu28, Leu31… Expand
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