Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells

@article{Noma1999RegulationON,
  title={Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells},
  author={T. Noma and Yong-Shik Yoon and Y. Yamashiro and K. Fujisawa and A. Nakazawa},
  journal={Neuroscience Letters},
  year={1999},
  volume={272},
  pages={45-48}
}
  • T. Noma, Yong-Shik Yoon, +2 authors A. Nakazawa
  • Published 1999
  • Biology, Medicine
  • Neuroscience Letters
  • To examine the signals that regulate NeuroD expression, we analyzed the effects of activation of two major signal pathways, the protein kinase A (PKA) pathway and the protein kinase C (PKC) pathway, on the expression of NeuroD in Y79human retinoblastoma cells. Activation of PKC resulted in marked induction of NeuroD mRNA and NeuroD protein. NeuroD mRNA induction was inhibited by calphostin C, an inhibitor of PKC. On the other hand, stimulation of PKA by forskolin had a weak suppressive effect… CONTINUE READING
    3 Citations
    Transcriptional response to the neuroleptic‐like compound Ampullosporin A in the rat ketamine model
    • 6
    Dynamics of nucleotide metabolism as a supporter of life phenomena.
    • T. Noma
    • Biology, Medicine
    • The journal of medical investigation : JMI
    • 2005
    • 84
    • PDF

    References

    SHOWING 1-10 OF 16 REFERENCES
    cDNA cloning and expression analysis of NeuroD mRNA in human retina.
    • 25
    Cell lineage determination and the control of neuronal identity in the neural crest.
    • 122
    • PDF