Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells

@article{Noma1999RegulationON,
  title={Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells},
  author={T. Noma and Yong-Shik Yoon and Y. Yamashiro and K. Fujisawa and A. Nakazawa},
  journal={Neuroscience Letters},
  year={1999},
  volume={272},
  pages={45-48}
}
  • T. Noma, Yong-Shik Yoon, +2 authors A. Nakazawa
  • Published 1999
  • Biology, Medicine
  • Neuroscience Letters
    • To examine the signals that regulate NeuroD expression, we analyzed the effects of activation of two major signal pathways, the protein kinase A (PKA) pathway and the protein kinase C (PKC) pathway, on the expression of NeuroD in Y79human retinoblastoma cells. Activation of PKC resulted in marked induction of NeuroD mRNA and NeuroD protein. NeuroD mRNA induction was inhibited by calphostin C, an inhibitor of PKC. On the other hand, stimulation of PKA by forskolin had a weak suppressive effect… CONTINUE READING
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