Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses

@article{Huang2000RegulationON,
  title={Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses},
  author={Y. Z. Huang and S. Won and D. Ali and Q. Wang and M. Tanowitz and Quan Du and K. Pelkey and D. Yang and W. C. Xiong and M. Salter and Lin Mei},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={443-455}
}
  • Y. Z. Huang, S. Won, +8 authors Lin Mei
  • Published 2000
  • Biology, Medicine
  • Neuron
  • Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules… CONTINUE READING
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