Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses

  title={Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses},
  author={Y. Z. Huang and S. Won and D. Ali and Q. Wang and M. Tanowitz and Quan Du and K. Pelkey and D. Yang and W. C. Xiong and M. Salter and Lin Mei},
  • Y. Z. Huang, S. Won, +8 authors Lin Mei
  • Published 2000
  • Biology, Medicine
  • Neuron
  • Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules… CONTINUE READING
    356 Citations
    Ligand-Dependent Recruitment of the ErbB4 Signaling Complex into Neuronal Lipid Rafts
    • 125
    • PDF
    On the Modulatory Roles of Neuregulins/ErbB Signaling on Synaptic Plasticity
    • 4
    • Highly Influenced
    • PDF
    Neuregulin1-ErbB4 signaling mediates synaptic maturation and induces dendritic branching in hippocampal neurons
    • Highly Influenced
    Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
    • 143
    Erbin Is a Protein Concentrated at Postsynaptic Membranes That Interacts with PSD-95*
    • 95
    • PDF
    Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function
    • 32


    SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
    • 582
    Binding of neuroligins to PSD-95.
    • 677
    Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses.
    • 167
    Regulation of Neuregulin-Mediated Acetylcholine Receptor Synthesis by Protein Tyrosine Phosphatase SHP2
    • 46
    • PDF
    Neuregulin-β induces expression of an NMDA-receptor subunit
    • 236
    Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc.
    • 15
    • Highly Influential
    Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
    • 1,812
    • Highly Influential