Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.

@article{Storm2007RegulationON,
  title={Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.},
  author={Mike P. Storm and Heather K. Bone and Craig G Beck and Pierre-Yves Bourillot and Val{\'e}rie Schreiber and Teresa Damiano and Adam Nelson and Pierre Savatier and Melanie J. Welham},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 9},
  pages={6265-73}
}
Embryonic stem (ES) cell pluripotency is regulated by a combination of extrinsic and intrinsic factors. Previously we have demonstrated that phosphoinositide 3-kinase (PI3K)-dependent signaling is required for efficient self-renewal of murine ES cells. In the study presented here, we have investigated the downstream molecular mechanisms that contribute to the ability of PI3Ks to regulate pluripotency. We show that inhibition of PI3K activity with either pharmacological or genetic tools results… CONTINUE READING
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