Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase.

@article{Sopjani2010RegulationON,
  title={Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase.},
  author={Mentor Sopjani and Shefalee K. Bhavsar and Scott Fraser and Bruce E. Kemp and Michael F{\"o}ller and Florian Lang},
  journal={Molecular membrane biology},
  year={2010},
  volume={27 2-3},
  pages={137-44}
}
AMP-activated protein kinase (AMPK), a serine/threonine kinase activated upon energy depletion, stimulates energy production and limits energy utilization. It has previously been shown to enhance cellular glucose uptake through the GLUT family of facilitative glucose transporters. The present study explored the possibility that AMPK may regulate Na+-coupled glucose transport through SGLT1 (SLC5A1). To this end, SGLT1 was expressed in Xenopus oocytes with and without AMPK and electrogenic… CONTINUE READING
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