Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway.

@article{Weaver2013RegulationON,
  title={Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway.},
  author={Jessica R. Weaver and David A. Taylor-Fishwick},
  journal={Molecular and cellular endocrinology},
  year={2013},
  volume={369 1-2},
  pages={35-41}
}
NADPH oxidase-1 (NOX-1) is upregulated in beta cells in response to pro-inflammatory cytokines. Inhibition of NADPH oxidase activity blocked stimulated NOX-1 expression (p<0.05). Regulation of NOX-1 expression in beta cells followed modulation of cellular reactive oxygen species (ROS); pro-oxidants increased NOX-1 (p<0.001) and anti-oxidants decreased NOX-1 (p<0.05). Activation of Src-kinase followed ROS elevation. Inhibition of Src-kinase decreased NOX-1 expression (p<0.01). Beta cell… CONTINUE READING