Regulation of NO-elicited pulmonary artery relaxation and guanylate cyclase activation by NADH oxidase and SOD.

@article{Gupte1999RegulationON,
  title={Regulation of NO-elicited pulmonary artery relaxation and guanylate cyclase activation by NADH oxidase and SOD.},
  author={Sachin A. Gupte and Tasneem Rupawalla and Kamal M Mohazzab-H and Michael S. Wolin},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1999},
  volume={276 5},
  pages={H1535-H1542}
}
We have previously reported that inhibition of Cu/Zn superoxide dismutase (SOD) in endothelium-removed bovine pulmonary arteries (BPA) attenuates nitrovasodilator-elicited relaxation and that a NADH oxidase linked to the redox status of cytosolic NADH is the major detectable source of superoxide ([Formula: see text]) production in this tissue. In the present study, we investigated whether NADH oxidase-derived[Formula: see text] participated in inhibition of nitrovasodilator-elicited relaxation… CONTINUE READING

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