Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A

@article{Wang1994RegulationON,
  title={Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A},
  author={Lu-Yang Wang and Bev A. Orser and David L. Brautigan and John F. MacDonald},
  journal={Nature},
  year={1994},
  volume={369},
  pages={230-232}
}
PHOSPHORYLATION of glutamate receptors is probably an important mechanism for modulating excitatory transmission1–4. However, there is little direct evidence to indicate which protein phosphatases can dephosphorylate glutamate5 or other ligand-gated channels6, although it is known that protein phosphatases 1 and 2A play a major part in modulating voltage7–10 and second-messenger-gated channels11. Here we report that in cultured hippocampal neurons, the N-methyl-D-aspartate (NMDA) receptor can… CONTINUE READING
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