Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain

@article{Tingley1993RegulationON,
  title={Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain},
  author={Whittemore G. Tingley and Katherine W. Roche and Angela K. Thompson and Richard L. Huganir},
  journal={Nature},
  year={1993},
  volume={364},
  pages={70-73}
}
THE NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity1–3. Molecular cloning has demonstrated that NMDA receptors consist of several homologous subunits (NMDAR1, 2A–2D)4–7. A variety of studies have suggested that protein phosphorylation of NMDA receptors may regulate their function7–12 and play a role in many forms of synaptic plasticity such as long-term potentiation13,14. We have examined the phosphorylation of… CONTINUE READING
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