Regulation of NK cell responsiveness to achieve self‐tolerance and maximal responses to diseased target cells

@article{Joncker2008RegulationON,
  title={Regulation of NK cell responsiveness to achieve self‐tolerance and maximal responses to diseased target cells},
  author={Nathalie T. Joncker and D. Raulet},
  journal={Immunological Reviews},
  year={2008},
  volume={224}
}
Summary: Inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules govern the capacity of natural killer (NK) cells to attack class I‐deficient cells (‘missing‐self recognition’). These receptors are expressed stochastically, such that the panel of expressed receptors varies between NK cells. This review addresses how the activity of NK cells is coordinated in the face of this variation to achieve a repertoire that is self‐tolerant and optimally reactive with… Expand
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  • 42
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  • 748
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References

SHOWING 1-10 OF 120 REFERENCES
Licensing of natural killer cells by self‐major histocompatibility complex class I
  • 230
Self‐tolerance of Human Natural Killer Cells Lacking Self‐HLA‐specific Inhibitory Receptors
  • 10
Licensing of natural killer cells by host major histocompatibility complex class I molecules
  • 1,182
  • Highly Influential
Human NK cell education by inhibitory receptors for MHC class I.
  • 1,000
  • PDF
Major histocompatibility complex genes determine natural killer cell tolerance
  • 72
How do natural killer cells find self to achieve tolerance?
  • 196
Cumulative Inhibition of NK Cells and T Cells Resulting from Engagement of Multiple Inhibitory Ly49 Receptors1
  • 37
  • PDF
...
1
2
3
4
5
...