Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells.

@article{Joncker2008RegulationON,
  title={Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells.},
  author={Nathalie T. Joncker and David H Raulet},
  journal={Immunological reviews},
  year={2008},
  volume={224},
  pages={
          85-97
        }
}
Inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules govern the capacity of natural killer (NK) cells to attack class I-deficient cells ('missing-self recognition'). These receptors are expressed stochastically, such that the panel of expressed receptors varies between NK cells. This review addresses how the activity of NK cells is coordinated in the face of this variation to achieve a repertoire that is self-tolerant and optimally reactive with diseased… CONTINUE READING

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