Regulation of NK cell function by human granulocyte arginase.

@article{Oberlies2009RegulationON,
  title={Regulation of NK cell function by human granulocyte arginase.},
  author={Johanna Oberlies and Carsten Watzl and Thomas Giese and Claudia Luckner and Pascale Kropf and Ingrid M{\"u}ller and Anthony D. Ho and Markus Munder},
  journal={Journal of immunology},
  year={2009},
  volume={182 9},
  pages={
          5259-67
        }
}
The arginine-hydrolyzing enzyme arginase is constitutively expressed by human polymorphonuclear granulocytes (PMN). Upon PMN cell death arginase is liberated and depletes arginine in the microenvironment. This amino acid depletion suppresses T cell proliferation and cytokine secretion and emerges as a key mechanism of immunosuppression during chronic inflammation and tumor growth. Here we show that PMN arginase also severely impairs key functions of primary human NK cells as well as IL-2… CONTINUE READING

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