Regulation of NHE-1 promoter in mammalian myocardium.

  title={Regulation of NHE-1 promoter in mammalian myocardium.},
  author={W W Yang and Jason R. B. Dyck and Hongyu Wang and Larry Fliegel},
  journal={The American journal of physiology},
  volume={270 1 Pt 2},
The Na+/H exchanger (NHE-1) is an integral membrane protein responsible for intracellular pH regulation in the myocardium and other tissues. The NHE-1 isoform is universally distributed in mammalian cells. We examined regulation of a 1.1-kb fragment of the NHE-1 promoter in neonatal rat cardiomyocytes. Deletion of most of the promoter up to an AP-2 site reduced activity 75%. Further deletion of the promoter or mutation of the AP-2 site reduced or eliminated activity almost completely. Gel… CONTINUE READING