Regulation of NF-κB by deubiquitinases.

  title={Regulation of NF-κB by deubiquitinases.},
  author={Edward William Harhaj and Vishva M. Dixit},
  journal={Immunological reviews},
  volume={246 1},
The nuclear factor-κB (NF-κB) pathway is a critical regulator of innate and adaptive immunity. Noncanonical K63-linked polyubiquitination plays a key regulatory role in NF-κB signaling pathways by functioning as a scaffold to recruit kinase complexes containing ubiquitin-binding domains. Ubiquitination is balanced by deubiquitinases that cleave polyubiquitin chains and oppose the function of E3 ubiquitin ligases. Deubiquitinases therefore play an important role in the termination of NF-κB… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
95 Citations
217 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 95 extracted citations


Publications referenced by this paper.
Showing 1-10 of 217 references

Similar Papers

Loading similar papers…