Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

  title={Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination},
  author={Haiying Li and Tobias Wittwer and Axel W. Weber and Heike W Schneider and Rita Moreno and Gabriel N. Maine and Michael Kracht and Michael Schmitz and Ezra Burstein},
The nuclear factor (NF)-κB transcription factor has essential roles in inflammation and oncogenesis. Its ubiquitous RelA subunit is regulated by several post-translational modifications, including phosphorylation, ubiquitination and acetylation. Ubiquitination promotes the termination of RelA-dependent transcription, but its regulation is incompletely understood. Through mass spectrometry analysis of ubiquitinated RelA, we identified seven lysines that were attached to degradative and non… CONTINUE READING
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