Regulation of NF-κB Nuclear Activity in Peripheral Blood Mononuclear Cells: Role of CD28 Antigen

@inproceedings{Romano1994RegulationON,
  title={Regulation of NF-κB Nuclear Activity in Peripheral Blood Mononuclear Cells: Role of CD28 Antigen},
  author={Maria Romano and Rita Bisogni and Annalisa Lamberti and Maria Caterina Turco and Antonello Petrella and Pierfrancesco Tassone and Ren{\'e} A. W. van Lier and Salvatore Formisano and Salvatore Venuta},
  year={1994}
}
Abstract The NF-κB/rel family of transcription factors regulates the expression of a number of genes, including interleukin 2 (IL-2), IL-2 receptor a chain (Tac), and others, controlling T lymphocyte activation. The CD28 antigen is involved in regulation of T cell activation. To investigate whether CD28 antigen regulates NF-κB factors, we analyzed the effect of an anti-CD28 monoclonal antibody (mAb), CLB-CD28/1, on the nuclear activity of NF-κB complexes in resting and CD3-activated peripheral… CONTINUE READING