Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.

@article{Stegert2005RegulationON,
  title={Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.},
  author={Mario R. Stegert and Alexander Hergovich and Rastislav Tamaskovic and Samuel J Bichsel and Brian A. Hemmings},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 24},
  pages={11019-29}
}
NDR protein kinases are involved in the regulation of cell cycle progression and morphology. NDR1/NDR2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site Ser281/Ser282 and the hydrophobic motif phosphorylation site Thr444/Thr442. Autophosphorylation of NDR is responsible for phosphorylation on Ser281/Ser282, whereas Thr444/Thr442 is targeted by an upstream kinase. Here we show that MST3, a mammalian Ste20-like protein kinase, is able to phosphorylate NDR… CONTINUE READING
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