Regulation of NADPH oxidases in skeletal muscle.

@article{Ferreira2016RegulationON,
  title={Regulation of NADPH oxidases in skeletal muscle.},
  author={Leonardo F Ferreira and Orlando Laitano},
  journal={Free radical biology & medicine},
  year={2016},
  volume={98},
  pages={
          18-28
        }
}
The only known function of NAD(P)H oxidases is to produce reactive oxygen species (ROS). Skeletal muscles express three isoforms of NAD(P)H oxidases (Nox1, Nox2, and Nox4) that have been identified as critical modulators of redox homeostasis. Nox2 acts as the main source of skeletal muscle ROS during contractions, participates in insulin signaling and glucose transport, and mediates the myocyte response to osmotic stress. Nox2 and Nox4 contribute to skeletal muscle abnormalities elicited by… CONTINUE READING
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