Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.

@article{Manea2007RegulationON,
  title={Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.},
  author={Adrian Manea and Simona A Manea and Anca Violeta Gafencu and Monica Raicu},
  journal={Archives of physiology and biochemistry},
  year={2007},
  volume={113 4-5},
  pages={163-72}
}
Accumulating evidence demonstrates the involvement of oxidative stress in the pathophysiology of cardiovascular diseases. The molecular mechanisms accountable for the increased production of reactive oxygen species remain uncertain. Among others, NADPH oxidase is one of the most important sources of superoxide in vascular cells. Here we investigate the role of NF-kB in the regulation of p22(phox) subunit and NADPH oxidase activity, in human aortic smooth muscle cells. Overexpression of p65/RelA… CONTINUE READING