Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.

@article{Pendyala2009RegulationON,
  title={Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.},
  author={Srikanth Pendyala and Peter V. Usatyuk and Irina A. Gorshkova and Joe G. N. Garcia and Viswanathan Natarajan},
  journal={Antioxidants & redox signaling},
  year={2009},
  volume={11 4},
  pages={841-60}
}
The generation of reactive oxygen species (ROS) in the vasculature plays a major role in the genesis of endothelial cell (EC) activation and barrier function. Of the several potential sources of ROS in the vasculature, the endothelial NADPH oxidase family of proteins is a major contributor of ROS associated with lung inflammation, ischemia/reperfusion injury, sepsis, hyperoxia, and ventilator-associated lung injury. The NADPH oxidase in lung ECs has most of the components found in phagocytic… CONTINUE READING
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