Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source

@inproceedings{Deshayes2013RegulationOM,
  title={Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source},
  author={Caroline Deshayes and Shiva kumar Angala and Estelle Marion and Ir{\`e}ne Brandli and J{\'e}r{\'e}mie Babonneau and Laurent Preisser and Sara Eyangoh and Yves Delneste and Pierre Legras and Chantal de Chastellier and Timothy P Stinear and Mary Jackson and Laurent Marsollier},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
BACKGROUND Mycobacterium ulcerans, a slow-growing environmental bacterium, is the etiologic agent of Buruli ulcer, a necrotic skin disease. Skin lesions are caused by mycolactone, the main virulence factor of M. ulcerans, with dermonecrotic (destruction of the skin and soft tissues) and immunosuppressive activities. This toxin is secreted in vesicles that enhance its biological activities. Nowadays, it is well established that the main reservoir of the bacilli is localized in the aquatic… CONTINUE READING
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Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

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